Characteristics of the sequence effect in Parkinson's disease
Identifieur interne : 000782 ( Main/Exploration ); précédent : 000781; suivant : 000783Characteristics of the sequence effect in Parkinson's disease
Auteurs : Suk Yun Kang [États-Unis, Corée du Sud] ; Toshiaki Wasaka [États-Unis] ; Ejaz A. Shamim [États-Unis] ; Sungyoung Auh [États-Unis] ; Yoshino Ueki [États-Unis] ; Grisel J. Lopez [États-Unis] ; Tetsuo Kida [États-Unis] ; Seung-Hyun Jin [États-Unis] ; Nguyet Dang [États-Unis] ; Mark Hallett [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-10-15.
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Abstract
The sequence effect (SE) in Parkinson's disease (PD) is progressive slowing of sequential movements. It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer‐based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo‐controlled, four‐way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE. © 2010 Movement Disorder Society.
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DOI: 10.1002/mds.23251
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It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer‐based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo‐controlled, four‐way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE. © 2010 Movement Disorder Society.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>États-Unis</li></country><region><li>Maryland</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Kang, Suk Yun" sort="Kang, Suk Yun" uniqKey="Kang S" first="Suk Yun" last="Kang">Suk Yun Kang</name></region><name sortKey="Auh, Sungyoung" sort="Auh, Sungyoung" uniqKey="Auh S" first="Sungyoung" last="Auh">Sungyoung Auh</name><name sortKey="Dang, Nguyet" sort="Dang, Nguyet" uniqKey="Dang N" first="Nguyet" last="Dang">Nguyet Dang</name><name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name><name sortKey="Jin, Seung Yun" sort="Jin, Seung Yun" uniqKey="Jin S" first="Seung-Hyun" last="Jin">Seung-Hyun Jin</name><name sortKey="Kida, Tetsuo" sort="Kida, Tetsuo" uniqKey="Kida T" first="Tetsuo" last="Kida">Tetsuo Kida</name><name sortKey="Lopez, Grisel J" sort="Lopez, Grisel J" uniqKey="Lopez G" first="Grisel J." last="Lopez">Grisel J. Lopez</name><name sortKey="Shamim, Ejaz A" sort="Shamim, Ejaz A" uniqKey="Shamim E" first="Ejaz A." last="Shamim">Ejaz A. Shamim</name><name sortKey="Shamim, Ejaz A" sort="Shamim, Ejaz A" uniqKey="Shamim E" first="Ejaz A." last="Shamim">Ejaz A. Shamim</name><name sortKey="Ueki, Yoshino" sort="Ueki, Yoshino" uniqKey="Ueki Y" first="Yoshino" last="Ueki">Yoshino Ueki</name><name sortKey="Wasaka, Toshiaki" sort="Wasaka, Toshiaki" uniqKey="Wasaka T" first="Toshiaki" last="Wasaka">Toshiaki Wasaka</name></country><country name="Corée du Sud"><noRegion><name sortKey="Kang, Suk Yun" sort="Kang, Suk Yun" uniqKey="Kang S" first="Suk Yun" last="Kang">Suk Yun Kang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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